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dc.coverage.spatialOXFORD
dc.creatorGarcia-Beltran, Olimpo
dc.creatorCassels, Bruce K.
dc.creatorMena, Natalia
dc.creatorNunez, Marco T.
dc.creatorYanez, Osvaldo
dc.creatorCaballero, Julio
dc.date.accessioned2017-04-27T18:49:33Z
dc.date.available2017-04-27T18:49:33Z
dc.date.issued2014
dc.identifier.issn0040-4039
dc.identifier.urihttp://hdl.handle.net/10533/196880
dc.description.abstractIn this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Possible interference with other analytes was examined, and the decrease of the fluorescence of JB at 510 nm when it reacts with Cu2+ was shown to be highly selective. This probe accumulates in the plasmalemma of human neuroblastoma SH-SY5Y cells. Molecular dynamics (MD) simulations revealed thatJB interacts with the lipid bilayer at the level of the glycerol moieties. (C) 2013 Elsevier Ltd. All rights reserved.
dc.language.isoENG
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.titleA coumarinylaldoxime as a specific sensor for cu2+ and its biological application
dc.typeArticulo
dc.bibliographicCitation.stpage873
dc.bibliographicCitation.endpage876
dc.identifier.folioVIU110063
dc.country.isoGBR
dc.description.citasisi2
dc.description.conicytprogramFONDEF
dc.description.emailojgarciab@ug.uchile.cl
dc.description.investmentarticleFONDEF [VIU-110063]; FONDECYT [1130141]
dc.identifier.isiWOS:000330604500023
dc.relation.projectidinfo:eu-repo/grantAgreement/Fondef/VIU110063
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.title.journalTETRAHEDRON LETTERS
dc.title.journalabbreviationTetrahedron Lett.
dc.type.driverinfo:eu-repo/semantics/article
dc.description.shortconicytprogramFONDEF
dc.identifier.eissn0
dc.description.agradThis work was supported by FONDEF VIU-110063, and by FONDECYT Grant # 1130141.
dc.type.openaireinfo:eu-repo/semantics/publishedVersion


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