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dc.creatorBurton, Ana
dc.creatorMaskarinec, Gertraud
dc.creatorPerez-Gomez, Beatriz
dc.creatorVachon, Celine
dc.creatorMiao, Hui
dc.creatorLajous, Martin
dc.creatorLopez-Ridaura, Ruy
dc.creatorRice, Megan
dc.creatorPereira, Ana
dc.creatorGarmendia, Maria Luisa
dc.date.accessioned2018-07-13T16:07:16Z
dc.date.available2018-07-13T16:07:16Z
dc.date.issued2017es_CL
dc.identifier.urihttp://hdl.handle.net/10533/215542
dc.description.abstractMammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. Methods and findings . We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity-and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. In all, 4,534 women were premenopausal, and 6,481 postmenopausal, at the time of mammography. A large age-adjusted difference in percent MD (PD) between post-and premenopausal women was apparent (-0.46 cm [95% CI: -0.53, -0.39]) and appeared greater in women with lower breast cancer risk profiles; variation across population groups due to heterogeneity (I-2) was 16.5%. Among premenopausal women, the root PD difference per 10-year increase in age was -0.24 cm (95% CI: -0.34, -0.14; I-2 = 30%), reflecting a compositional change (lower dense area and higher non-dense area, with no difference in breast area). In postmenopausal women, the corresponding difference in root PD (-0.38 cm [95% CI: -0.44, -0.33]; I-2 = 30%) was additionally driven by increasing breast area. The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature. Conclusions .Declines in MD with increasing age are present premenopausally, continue postmenopausally, and are most pronounced over the menopausal transition. These effects were highly consistent across diverse groups of women worldwide, suggesting that they result from an intrinsic biological, likely hormonal, mechanism common to women. If cumulative breast density is a key determinant of breast cancer risk, younger ages may be the more critical periods for lifestyle modifications aimed at breast density and breast cancer risk reductiones_CL
dc.language.isoeng
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relation.urihttp://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002335es_CL
dc.rightsinfo:eu-repo/semantics/openAccesses_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.titleMammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwidees_CL
dc.typeArticulo
dc.bibliographicCitation.endpage
dc.identifier.folio1130277es_CL
dc.relation.projectidinfo:eu-repo/grantAgreement//1130277es_CL
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.title.journalPlos Medicinees_CL
dc.type.driverinfo:eu-repo/semantics/article
dc.type.openaireinfo:eu-repo/semantics/publishedVersion


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