Role of the cys loop and transmembrane domain in the allosteric modulation of alpha 4 beta 2 nicotinic acetylcholine receptors

Abstract

Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using alpha 4 beta 2 nicotinic acetylcholine receptors and the alpha 4 beta 2-selective positive mo