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dc.creatorCardenas-Trivino, Galo
dc.creatorElgueta, Carolina
dc.creatorVergara, Luis
dc.creatorOjeda, Javier
dc.creatorValenzuela, Ariel
dc.creatorCruzat-Contreras, Christian
dc.description.abstractMetal colloids in 2 propanol using nanoparticles (NPs) of copper, nickel and cobalt were prepared by Chemical Liquid Deposition (CLD) method. The resulting colloidal dispersions were characterized by Transmission Electron Microscopy (TEM). The colloids were supported in chitosan. Then, microbiological assays were performed using E. coil and S. aureus in order to determine the bactericide/bacteriostatic activity of nanoparticles (NPs) trapped or chelated with chitosan. Finally, the toxicity of the metal colloids Cu, Ni and Co was tested. Bio-assays were conducted in three different animal species. First of all on earth warms (Eisenia foetida) to evaluate the toxicity and the biocompatibility of chitosan in lactic acid (1% and 0.5%). Secondly bio-assay done in fishes (rainbow trout), the liver toxicity of NPs in vivo was evaluated. Finally, a bio-assay was conducted in Sprange-Dawley rats of 100 g weight, which were injected intraperitoneally with different solutions of chitosan metal colloids. Then, the minimum and maximum concentration were determined for copper, nickel and cobalt. The purpose of the use of chitosan was acting as a carrier for some magnetic NPs, which toxicity would allow to obtain new polymeric materials with potential applications as magnet future drugs carrier. (C) 2017 Elsevier B.V. All rights reserved.es_CL
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
dc.titleChitosan doped with nanoparticles of copper, nickel and cobaltes_CL
dc.title.journalInternational Journal Of Biological Macromoleculeses_CL

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