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dc.creatorCardenas-Trivino, Galo
dc.creatorRuiz-Parra, Macarena
dc.creatorVergara-González, Luis
dc.creatorOjeda-Oyarzun, Javier
dc.creatorSolorzano, Guillermo
dc.date.accessioned2019-03-26T18:14:17Z
dc.date.available2019-03-26T18:14:17Z
dc.date.issued2017es_CL
dc.identifier.urihttp://hdl.handle.net/10533/233025
dc.description.abstractA study on the nanoparticles size and the antibacterial properties of hyaluronic acid (HA) doped with nanoparticles is reported. Nanoparticles fromgold, silver, copper, and silver palladiumwithHA support were performed. The solvated metal atomdispersion (SMAD) method with 2-propanol and HA was used. High-resolution transmission electron microscopy (HRTEM), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were conducted. The average sizes of nanoclusters were as follows: HA-Au = 17.88 nm; HA-Ag = 50.41 nm; HA-Cu = 13.33 nm; and HA-AgPd = 33.22 nm. The antibacterial activity of solutions and films containing nanoparticles against American Type Culture Collection (ATCC) bacterial strains Escherichia coli (EC), Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), and Pseudomonas aeruginosa (PA) was determined. Inhibition was observed for HA-Ag, HA-Cu, and HA-AgPd. Toxicological tests were performed in rats that were injected intraperitoneally with two concentrations of gold, copper, silver, and silver-palladium nanoparticles. No alterations in hepatic parameters, including ALT (alanine aminotransferase), GGT (gamma-glutamyl transpeptidase) bilirubin, and albumin, were observed after 14 days. These films could be used as promoters of skin recovery and Grades I and II cutaneous burns and as scaffolds.es_CL
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relation.urihttps://www.hindawi.com/journals/jnm/2017/9573869/es_CL
dc.rightsinfo:eu-repo/semantics/openAccesses_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.titleSynthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticleses_CL
dc.typeArticulo
dc.identifier.folio1140025es_CL
dc.relation.projectidinfo:eu-repo/grantAgreement//1140025es_CL
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.title.journalJournal Of Nanomaterials (PRINT)es_CL
dc.type.driverinfo:eu-repo/semantics/article
dc.type.openaireinfo:eu-repo/semantics/publishedVersion


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