A conserved homodimeric interface of the Hanta virus Gc glycoprotein directs viral particle assembly, acid-induced spike dissociation and membrane fusion

Abstract

Rodent-transmitted hantaviruses (Bunyaviriales order) are human pathogens that can reach fatality rates up to 50%. Their envelope glycoproteins, Gn and Gc, are derived from a precursor polyprotein and upon assembly onto viral particles they form (Gn/Gc)4