Pharmacological modulation of heme oxygenase-1 activity blocks herpes simplex virus infection of human neuronal SH-SY5Y cells

Abstract

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) elicit lifelong infections in humans establishing latency in neurons, from which they may reactivate. Previous reports suggest that HSV modulates oxidative stress within infected cells and that alteri