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dc.creatorBaudrand, René
dc.creatorVaidya, Anand
dc.date.accessioned2021-08-23T22:59:53Z
dc.date.available2021-08-23T22:59:53Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10533/252725
dc.description.abstractA substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and non-classical variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.
dc.language.isoeng
dc.relation.urihttps://doi.org/10.3390/ijms19020546
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.titleThe Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor
dc.typeArticulo
dc.description.conicytinstrumentRegular 2015
dc.identifier.folio1150327
dc.description.conicytprogramFONDECYT
dc.relation.contesthandle/10533/111557
dc.rights.driverinfo:eu-repo/semantics/article
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.title.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.relation.instrumenthandle/10533/111541
dc.relation.programhandle/10533/108045
dc.description.shortconicytprogramFONDECYT
dc.type.openaireinfo:eu-repo/semantics/publishedVersion


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