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dc.creatorBaudrand, René
dc.creatorVaidya, Anand
dc.date.accessioned2021-08-23T23:00:04Z
dc.date.available2021-08-23T23:00:04Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10533/252751
dc.description.abstractPurpose of reviewThe present review highlights recent investigations in the prior 18 months focusing on the role of dysregulated cortisol physiology in obesity as a potential modifiable mechanism in the pathogenesis of obesity-related cardiometabolic disorders.Recent findingsGiven the clinical resemblance of obesity-related metabolic disorders with the Cushing's syndrome, new studies have investigated the intracellular regulation and metabolism of cortisol, new measurements of cortisol in scalp hair as a tool for long-term exposure to cortisol, and the cortisol-mineralocorticoid receptor pathway. Thus, current and future pharmacological interventions in obesity may include specific inhibition of steroidogenic and regulatory enzymes as well as antagonists of the mineralocorticoid and glucocorticoid receptors.SummaryThe understanding of how adrenal function is challenged by the interplay of our genetic and environmental milieu has highlighted the importance of inappropriate cortisol regulation in cardiometabolic disorders. Increased adipose tissue in obesity is associated with hypothalamic-pituitary-adrenal axis overactivation, increased cortisol production at the local tissue level, and probably higher mineralocorticoid receptor activation in certain tissues.
dc.language.isoeng
dc.relation.urihttps://doi.org/10.1097/MED.0000000000000152
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.titleCortisol dysregulation in obesity-related metabolic disorders
dc.typeArticulo
dc.description.conicytinstrumentRegular 2015
dc.identifier.folio1150327
dc.description.conicytprogramFONDECYT
dc.relation.contesthandle/10533/111557
dc.rights.driverinfo:eu-repo/semantics/article
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.title.journalCURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
dc.relation.instrumenthandle/10533/111541
dc.relation.programhandle/10533/108045
dc.description.shortconicytprogramFONDECYT
dc.type.openaireinfo:eu-repo/semantics/publishedVersion


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